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Details Product Name: Estraderm TTS Drug Name: Estrogen-Estradiol Packaging Type: Packets of 8 x 25 mcg patches. Manufacturer: Novartis Use: Estraderm TTS is an estrogen replacement drug. It is used to reduce symptoms of menopause, including feelings of warmth in face, neck, and chest, and the sudden intense episodes of heat and sweating known as ``hot flashes.'' It is also used for other conditions caused by lack of estrogen, such as dry, itchy external genitals and vaginal irritation, and may be prescribed for teenagers who fail to mature at the usual rate. How to take it: Each Estraderm TTS patch is individually sealed in a protective pouch and is applied directly to the skin. A stiff protective liner covers the adhesive side of the patch. Remove the liner by sliding it sideways between your thumb and index finger. Holding the patch at one edge, remove the protective liner and discard it. Try to avoid touching the adhesive. Use immediately after removing the liner. Apply the adhesive side to a clean, dry area of your skin on the trunk of your body (including the buttocks and abdomen). Do not apply to your breasts or waist. Firmly press the patch in place with the palm of your hand for about 10 seconds, to make sure the edges are flat against your skin. Contact with water during bathing, swimming, or showering will not affect the patch. The application site must be rotated. Allow an interval of at least 1 week between applications to a particular site. If you forget to apply a new patch when you are supposed to, do it as soon as you remember. If it is almost time to change patches anyway, skip the one you missed and go back to your regular schedule. Do not apply more than one patch at a time. Side effects: Skin redness and irritation at the site of the patch.Less common or rare side effects may include: Abdominal cramps, bloating, breakthrough bleeding, breast enlargement, breast tenderness, change in cervical secretions, change in menstrual flow, change in sex drive, change in weight, darkening of skin, dizziness, fluid retention, growth of benign fibroid tumors in the uterus, headache, intolerance to contact lenses, migraine, nausea, rash, severe allergic reaction, spotting, vomiting, yellowing of eyes and skinOther side effects reported with estradiol include: Abnormal withdrawal bleeding, certain cancers, cardiovascular disease, depression, excessive growth of hair, gallbladder disease, hair loss, high blood pressure, reddened skin, skin discoloration, skin eruptions, twitching, vaginal yeast infection. Precautions: Estrogens should not be used if you have ever had breast or uterine cancer or a tumor promoted by estrogen. Also avoid estrogens if you are pregnant or think you are pregnant, if you have abnormal, undiagnosed genital bleeding, if you have blood clots or a blood clotting disorder, or if you have a history of blood clotting disorders associated with previous estrogen use. The risk of cancer of the uterus increases when estrogen is used for a long time or taken in large doses. There also may be increased risk of breast cancer in women who take estrogen for an extended period of time or in high doses. Women who take estrogen after menopause are more likely to develop gallbladder disease. Estrogen also increases the risk of blood clots. These blood clots can cause stroke, heart attack, or other serious disorders. While taking Estraderm, get in touch with your doctor right away if you notice any of the following: Abdominal pain, tenderness, or swellingAbnormal bleeding of the vaginaBreast lumpsCoughing up bloodPain in your chest or calvesSevere headache, dizziness, or faintnessSudden shortness of breathVision changesYellowing of the skinA complete medical and family history should be taken by your doctor before starting any estrogen therapy. In general, you should not take estrogen for more than 1 year without another physical examination by your doctor. Estraderm may cause fluid retention in some people. If you have asthma, epilepsy, migraine, or heart or kidney disease, use this medication cautiously. Estrogen therapy may cause uterine bleeding or breast pain. Possible food and drug interactions when taking this medication If you take certain other drugs while using Estraderm, the effects of either could be increased, decreased, or altered.