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Details What is Pantoprazole (Generic Protonix) used for? Pantoprazole (Generic Protonix) works by blocking acid production in the stomach. Protonix is used in the treatment of gastroesophageal reflux disease (GERD), in the treatment of duodenal ulcer, gastric ulcer, and long-term treatment of situations where the stomach is producing large amounts of acid, including Zollinger-Ellison syndrome. How to take Generic Protonix (Pantoprazole) Pantoprazole comes as a tablet that is taken by mouth. Generic Protonix is usually taken once a day. Protonix generally is recommended that tablets be taken approximately 30 minutes prior to meals for maximal effectiveness. Pantoprazoleis usually taken for 8 weeks, but your doctor may want you to take it for another 8 weeks if your esophagus has not healed. Follow the directions for using Generic Pantoprazole provided by your doctor. Do not break, crush, or chew before swallowing. Possible side effects of Pantoprazole Pantoprazole like other proton pump inhibitors is well-tolerated. The most common side effects are diarrhea, nausea, vomiting, constipation, rash and headaches. Dizziness, nervousness, abnormal heartbeat, muscle pain, weakness, leg cramps and water retention rarely occur. Drug interactions with Generic Protonix? Pantoprazole is less likely than omeprazole to interact with other drugs. The absorption of certain drugs may be affected by stomach acidity, and, as a result, pantoprazole and other PPIs that reduce stomach acid also reduce the absorption and concentration in blood of ketoconazole (Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin). This may lead to reduced effectiveness of ketoconazole or increased digoxin toxicity, respectively.