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Details Nexpro Generic Name: Nexium Packets of 15 x 20mg Tablets by Torrent Pharmaceiticals Indications GORD: Treatment of Reflux Oesophagitis (RO): 40mg once daily (od) for 4 weeks. An additional 4 weeks treatment is recommended for patients in whom oesophagitis has not healed or who have persistent symptoms. Long-term management of patients with healed oesophagitis to prevent relapse: 20mg od. Symptomatic treatment of GORD: 20mg od (in patients without oesophagitis). If symptoms have not been controlled after 4 weeks, the patient should be further investigated. Once symptoms have resolved, subsequent symptom control can be achieved using on-demand Nexium 20mg od, when needed. Helicobacter pylori eradication (in combination with appropriate antibiotics): Healing of H. pylori associated duodenal ulcers and prevention of relapse of peptic ulcers in patients with H. pylori associated ulcbders. Nexium 20mg, amoxycillin 1g, clarithromycin 500mg, all twice daily for 7 days. Renal impairment: No dose adjustment needed. Patients with severe renal insufficiency should be treated with caution. Hepatic impairment: No dose adjustment needed except in patients with severe liver impairment where a maximum daily dose of 20mg should not be exceeded. Children: Nexium should not be used in children since no data is available. CONTRA-INDICATIONS: Known hypersensitivity to esomeprazole, substituted benzimidazoles or any other constituents of Nexium. WARNINGS AND PRECAUTIONS: In the presence of any alarm symptoms and when gastric ulcer is suspected or present, malignancy should be excluded, as treatment may alleviate symptoms and delay diagnosis. Patients on long-term treatment should be kept under regular surveillance. Patients on on-demabdnd treatment should contact their physician if their symptoms change in character. When prescribing Nexium for on-demand therapy, the implications for interactions with other pharmaceuticals should be considered. When prescribing Nexium for H. pylori eradication, possible drug interactions for all components in the triple therapy, particularly clarithromycin, should be considered. Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.