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Details Tramal (Ultram) Generic Name: Tramadol Hydrocholoride Packets of 20 x 50 mg Capsules Manufactured by Ortho-McNeil Pharmaceuticals Use Tramal (Ultram) is a prescription medication indicated for the management of moderate to moderately severe pain. Tramal (Ultram) is a centrally acting synthetic analgesic, not a non-steroidal anti-inflammatory drug (NSAID). Tramal (Ultram) has no anti-inflammatory activity and no potential for prostaglandin-mediated side effects. Dosage Follow the directions for using this medicine as prescribed by your doctor. Do not exceed the recommended dosage or take for longer than required. Side effects The most frequently reported side effects experienced with Tramal (Ultram) were constipation, nausea, dizziness, headache, somnolence, and vomiting. Precautions Seizures have been reported in-patients receiving Tramal (Ultram). The risk of seizures is increased with doses of Tramal (Ultram) above the recommended range. Tramal (Ultram) increases the seizure risk in patients taking certain medications (e.g. tricyclic antidepressants, selective serotonin reuptake inhibitors, opioids) and may enhance the seizure risk in patients taking MAO inhibitors, neuroleptics, or other drugs that reduce the seizure threshold or in patients with a medical history that may suggest increased risk of seizure. Patients with a history of severe, life-threatening allergic (anaphylactoid) reactions to codeine and other opioids may be at risk and therefore should not receive Tramal (Ultram). Cases of abuse and dependence on Tramal (Ultram) have been reported. Tramal (Ultram) should not be used in opioid-dependent patients. Since Tramal (Ultram) can reinitiate physical dependence, it is not recommended for patients with a tendency to drug abuse, a history of drug dependence, or chronically using opioids.