Valdoxan® | Valdoxan (Agomelatine) - 25mg (28 Tablets)

Uses
Valdoxan, (active ingredient agomelatine), is the first in a new class of antidepressants called melatonergic agonists. This novel approach to treating depression has many advantages over current treatments. Valdoxan not only works effectively as an antidepressant, it has been shown to improve sleep/wake cycles without causing daytime sleepiness. Additionally, it doesn’t appear to have the side effect of loss of sexual desire or problems with stopping the drug (discontinuation symptoms) that other antidepressants do.

Dosage and administration
Clinical studies have shown that a dose of 25 mg of Valdoxan once daily in the hours before bed effectively treats major depressive disorders. Further studies showed that it works in adults of all ages and in elderly people. Another clinical trial showed that Valdoxan has a similar effectiveness to venlafaxine, which is commonly known as Effexor.

Side effects
The most common side effects associated with Valdoxan, seen in between 1% and 10% of patients, are headache, dizziness, sleepiness, insomnia, migraine, nausea, diarrhea, excessive sweating, and increases in anxiety. In some patients, liver enzymes were increased.

Most reported side effects were minor and came and went within the first two weeks of treatment. It is possible that some of the reported side effects were linked to depression rather than the drug.

Precautions
Valdoxan should not be used in patients who have liver problems like cirrhosis or active liver disease. It should not be taken by patients who are taking medicines that would slow down the breakdown of Valdoxan such as fluvoxamine (trade name Luvox) and the antibiotic ciprofloxacin (trade name Cipro). It should also not be taken by patients with age related dementia

You should not use Valdoxan if you suffer from hepatic impairment or in cases of concomitant use with potent CYP1A2 inhibitors.

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