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Contact us for availability Details Zidovir (Generic AZT / ZDV / Retrovir) Generic Name: Zidovudine Blister Strips of 10 x 300 mg Tablets Manufactured by Cipla Description Zidovudine, a thymidine analogue, is an anti-retroviral drug active against human immunodeficiency virus (HIV). Cellular thymidine kinase converts zidovudine into zidovudine monophosphate and further to the diphosphate. Zidovudine diphosphate is converted to the triphosphate derivative by other cellular enzymes. Zidovudine triphosphate interferes with the HIV viral RNA dependent DNA polymerase (reverse transcriptase), and thus inhibits viral replication. Zidovudine triphosphate also inhibits cellular aDNA polymerase at concentrations 100fold higher than those required to inhibit reverse transcriptase. In vitro, reverse transcriptase incorporates zidovudine triphos-phate into the growing chain of DNA, and the DNA chain is terminated. Indications Zidovir is indicated for the treatment of HIV infection when antiretroviral therapy is warranted. Therapy with zidovudine has been shown to prolong survival and decrease the incidence of opportunistic infections in patients with advanced HIV disease at initiation of therapy and to delay disease progression in asymptomatic HIV-infected patients. Other randomized studies suggest that the duration of the clinical benefit of monotherapy with zidovudine is time-limited. Zidovudine in combination with certain antiretroviral agents has been shown to be superior to monotherapy in one or more of the following: delaying death, delaying development of AIDS, increasing CD4 cell counts, and decreasing plasma HIV RNA. The complete prescribing information for each drug should be consulted before combination therapy which includes Zidovir is initiated. Further Information For further information, see Cipla's information page on Zidovir.